Molecular Attraction. VII.

Channel-facilitated molecular transport across membranes: attraction, repulsion, and asymmetry.

Transport of molecules across membrane channels is investigated theoretically using exactly solvable discrete stochastic site-binding models. It is shown that the interaction potential between molecules and the channel has a strong effect on translocation dynamics. The presence of attractive binding sites in the pore accelerates the particle current for small concentrations outside the membrane...

Some Molecular Collision Integrals for Point Attraction and Repulsion Potentials.

Molecular biology and clinical manifestation of hereditary factor VII deficiency.

Inherited factor VII (FVII) deficiency is a rare autosomal recessive disorder. Mutations and polymorphisms of the FVII gene were characterized in more than 40 unrelated patients with FVII deficiency. Among the 29 different mutations, the most frequent were Ala294 Val, Ala294Val;404delC, IVS7+7, and Val281 Phe. Four novel mutations (IVS2+1G>C, Arg247 Cys, Glu265 Lys, Asp343 His) were detected. T...

Molecular analysis of Polish patients with factor VII deficiency.

We analyzed the mutations in patients from 10 Polish kindreds with a bleeding diathesis due to factor VII deficiency. Patients from eight families had plasma levels of factor VII coagulant activity (VII:C) and factor VII antigen (VII:Ag) that were less than 4% of normal. The coding sequence of the factor VII gene was amplified from genomic DNA by polymerase chain reaction (PCR). Sequencing demo...

Clinical manifestations, management, and molecular genetics in congenital factor VII deficiency: the International Registry on Congenital Factor VII Deficiency (IRF7)

Factor VII deficiency is a rare bleeding disorder in which premature death may occur from severe bleeding. Up to now, our scientific knowledge on factor VII deficiency has been mainly based on reporting of single cases and groups of patients from confined geographical areas.1-3 To improve our insight and understanding of the epidemiology and the heterogeneity of factor VII deficiency through de...